A Combined Approach to the Treatment of Adults with Osteogenesis Imperfecta: (OSMOAJ) - Lupine Publishers

A Combined Approach to the Treatment of Adults with Osteogenesis Imperfecta by Jay R Shapiro in Orthopedics and Sports Medicine Open Access Journal (OSMOAJ) in Lupine Publishers

Osteogenesis Imperfecta (OI) is an inherited disorder of bone characterized by bone fragility and increased fracture risk affecting approximately 25,000 children and adults in the.com [1]. OI is caused by different gene mutations involving the synthesis of type I collagen alpha chains. Recently, mutations affecting post translational processing of type I collagen as well as several non-collagenous proteins (SP7. Osterix) involved in the Wnt signalling pathway have been recognized. To date, 19 genes are implicated in osteogenesis imperfecta phenotypes [2]. In individuals with OI fractures occur throughout the lifetime, more frequently at the extremes of age.

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